Adam Cribbs: PhD (Imperial college, London) in molecular immunology and now a computational biologist.
My passion is for quality reproducible science that has the power to change opinions about the world.
I am currently working as a Medical Research Council (MRC) fellow at the Computational Genomics and Training Centre (CGAT), University of Oxford.
Im also an immunologist with a focus on understanding how dysregulated epigenetic pathways in T cells contribute to autoimmunity.
I am currently applying my bioinformatic skills to answer important research questions in collaboration with a number of academics across the University of Oxford. Summaries of current ongoing projects are detailed here.
I began my scientific career at the Kennedy Institute of Rheumatology where I undertook a PhD investigating why regulatory T cells (Treg) were defective in Rheumatoid arthritis (RA). I identified that DNA methylation at the CTLA-4 promoter led to impaired Treg function that contributes to the inflammatory processes in RA
Following my PhD I moved to Prof Sir Marc Feldmann (known for the discovery of anti-TNF therapy in RA) and Prof Udo Oppermans laboratory at the Botnar research centre to investigate epigenetic pathways that are important for T and NK cell activation. During this time I was using a number of whole genome wide techniques to analyse the contribution of histone marks to autoimmunity
Despite developing extensive knowledge of experimental design and state-of-the art laboratory techniques, at the time I was unable to analyse the resulting data to a high standard, which motivated me to apply for my current MRC fellowship in computational biology based at the Weatherall Institute of Molecular Medicine (University of Oxford).
The CGAT training fellowship is a highly competitive program that has the remit of “training the future leaders in computational genomics”. Since starting the program, I have developed a number of computational skills that allow me to write complex code, enabling the difficult analysis and interpretation of next-generation sequencing data.
I am currently working on a number of really cool projects in collaboration with a number of scientists across the University of Oxford, summaries of these can be found here.